The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography.
نویسندگان
چکیده
BACKGROUND Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders. OBJECTIVE To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS. DESIGN Case series. SETTING Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS. RESULTS Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism. CONCLUSION Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
منابع مشابه
Teaching Neuroimages: Hypometabolism of the primary motor cortex in primary lateral sclerosis: The stripe sign.
A 47-year-old patient developed progressive upper limb weakness and hyperreflexia over 4 years. Lower limb examination had normal results. Nerve conduction, EMG, and brain and spine MRI had normal results. FDG-PET demonstrated severe bilateral hypometabolism in the primary motor cortex (figure, A and B). In the correct clinical context, this stripe of hypometabolism supports a diagnosis of prim...
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ورودعنوان ژورنال:
- Archives of neurology
دوره 67 1 شماره
صفحات -
تاریخ انتشار 2010